REST/NRSF-Interacting LIM Domain Protein, a Putative Nuclear Translocation Receptor
Open Access
- 1 December 2003
- journal article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 23 (24) , 9025-9031
- https://doi.org/10.1128/mcb.23.24.9025-9031.2003
Abstract
The transcriptional repressor REST/NRSF (RE-1 silencing transcription factor/neuron-restrictive silencer factor) and the transcriptional regulator REST4 share an N-terminal zinc finger domain structure involved in nuclear targeting. Using this domain as bait in a yeast two-hybrid screen, a novel protein that contains three LIM domains, putative nuclear localization sequences, protein kinase A phosphorylation sites, and a CAAX prenylation motif was isolated. This protein, which is localized around the nucleus, is involved in determining the nuclear localization of REST4 and REST/NRSF. We propose the name RILP, for REST/NRSF-interacting LIM domain protein, to label this novel protein. RILP appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors.Keywords
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