PROTECTIVE EFFECTS OF α-TOCOPHEROL AND COENZYME Q10 ON WARM ISCHEMIC DAMAGES OF THE RAT KIDNEY

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Abstract
Studies were done on the protective effects of .alpha.-tocopherol and coenzyme Q10 (COQ10) on warm ischemic damage to the rat kidney. Administration of .alpha.-tocopherol (10 mg/kg body wt/day) for 7 days or a single i.p. injection of CoQ10 (6 mg/kg body wt) increased the survival rate from 0 to 46.7% of the rats subjected to warm ischemia for 120 min. The administration of .alpha.-tocopherol and CoQ10 increased ATP in the renal tissue from 0.53 .+-. 0.18 to 0.92 .+-. 0.29, and from 0.64 .+-. 0.26 to 1.00 .+-. 0.54 .mu.mol/g wet weight, respectively, 4 h reperfusion after 120 min of warm ischemia. Serum creatinine levels of the surviving rats after 120 min of warm ischemia was 9.98 .+-. 0.19 mg/100 ml in the control group and 5.84 .+-. 0.95 and 7.27 .+-. 1.62 mg/100 ml, respectively, in .alpha.-tocopherol and COQ10 administered group, when determined 2 days after the operation. Apparently .alpha.-tocopherol and CoQ10 have a protective effect on warm ischemic damage to the rat kidney, demonstrated by an increase in ATP resynthesis after reflow following warm ischemia and by the maintenance of a lower serum creatinine level. This effect was accompanied by an increase in the survival rate of ischemic rats.

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