LYSOZYME AND LACTOFERRIN IN SPUTUM FROM PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG-DISEASE

  • 1 January 1984
    • journal article
    • research article
    • Vol. 65  (7) , 512-520
Abstract
The 2 basic proteins lysozyme and lactoferrin were isolated from solubilized mucoid sputum from patients with chronic bronchitis in 1 step by cation exchange chromatography. In sputa from 13 patients with chronic bronchitis, the mean concentrations were 0.4 g/l and 0.7 g/l, respectively, representing 6.6% and 11.5% of the total amount of solubilized protein. Lysozyme and the acid mucin glycoprotein of sputum formed aggregates at low ionic strength, probably as a result of electrostatic interactions between the 2. Although only aggregates were formed and not a viscoelastic fluid or a gel, these interactions may contribute to the viscoelastic properties of native sputum.

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