HISTOCOMPATIBILITY ANTIGENS AND GENETIC CONTROL OF THE IMMUNE RESPONSE IN GUINEA‐PIGS

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Abstract
Further breeding studies were carried out to investigate the polygenic control of the cellular immune response in the guinea pig to low doses of aspirin anhydride (ASAN), penicilloylated bovine immunoglobulin (BPO-BGG) and the multichain copolymer (T, G)-A-L [synthetic polypeptide containing Tyr, Glu, Ala and Lys]. Although responsiveness to these 3 antigens is controlled by 3 independently segregating loci, at least 1 gene required for these responses is linked to the strain 13 haplotype.