Evidence for Cerebellar-Frontal Subsystem Changes in Children Treated With Intrathecal Chemotherapy for Leukemia
Open Access
- 1 December 1998
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 55 (12) , 1561-1568
- https://doi.org/10.1001/archneur.55.12.1561
Abstract
INTRATHECAL methotrexate impairs proliferation of leptomeningeal leukemic cells, and is a major component of preventive central nervous system (CNS) treatment for childhood acute lymphoblastic leukemia (ALL).1 Reported neuroanatomical changes following methotrexate treatment include cerebral calcifications and atrophy,2,3 and children treated with both cranial irradiation (240 Gy) and methotrexate chemotherapy before the age of 5 years have shown decreases in measures of cerebellar morphology.4,5Keywords
This publication has 1 reference indexed in Scilit:
- Neuropsychological Effects of Childhood Cancer TreatmentJournal of Child Neurology, 1988