Significance of the urinary excretion of cells after experimental medullary necrosis.

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Abstract
Lesions of the renal pyramid were produced in male rats by the injection of ethyleneimine. The changes in the urinary excretion of cells were studied and the concentrating power of the kidneys was assessed by measuring the response to vasopressin. These results were related to the histological changes found in the kidneys at the end of the experiment. The changes in cell excretion rates were found to be a poor indicator of the severity of the lesion in the renal pyramid, the renal concentrating power being much better. These results are discussed in relation to analgesic nephritis in man. A substance is not necessarily harmless to the kidney even if it fails to raise the renal cell excretion rate.