The Cytotoxic Principles of Solanum incanum
- 1 March 1990
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 53 (2) , 513-516
- https://doi.org/10.1021/np50068a041
Abstract
In continuation of work on Solanum incanum a new steroidal alkaloid glycoside has been isolated from the fresh berries, which is named incanumine, and characterized as O(3)-{.beta.-D-xylopyranosyl-(1 .fwdarw. 3glu)-[.beta.-D-xylopyranosyl-(1 .fwdarw. 4rha)-.alpha.-L-rhamnopyranosyl-(1 .fwdarw. 4glu)]-.beta.-D-glucopyranosyl}-solasodine [1]. Solamargine, solasodine, ursolic acid, and ursolic acid derivatives (3-O-palmitoyl urosolic acid, 3-O-crotonyl ursolic acid, 3-O-propionyl ursolic acid) exhibited significant cytotoxic effects against human PLC/PRF/5 cells in vitro. Esterification of ursolic acid with aliphatic acids clearly enhanced the cytotoxic effects against human PLC/PRF/5 cells in vitro.This publication has 4 references indexed in Scilit:
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