Immunologic studies in lymphoma and leukemia, and exploration of antitumor immunotherapy

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Abstract
Prospective studies, conducted over a period of years, have demonstrated that survival with malignant lymphoma or chronic leukemia correlates with the status of patients' cellular immune reactivity. BCG vaccination can stimulate cellular immune responses of patients with well‐controlled neoplastic disease, and repeated vaccination with BCG‐cell mixtures induces both delayed hypersensitivity to antigens of the vaccine mixtures and general stimulation of this class of immune responses. An exploratory trial of immunologic stimulation in chronic myeloctyic leukemia has yielded unequivocally favorable results, and it appears that immunotherapy may contribute significantly to the control of several types of human neoplastic disease.