Nasal irritation and pulmonary toxicity of aliphatic amines in mice

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Abstract
The expiratory bradypnoea indicative of upper airway irritation in mice was evaluated during a 15‐min oronasal exposure to increasing concentrations of twenty aliphatic amines. The airborne concentration resulting in a 50% decrease in the respiratory rate of mice (RD50) was calculated for each test compound. Moreover, eight out of the twenty amines were tested for pulmonary toxicity in mice and for the effects of a 120‐min exposure on the respiratory rates of non‐anaesthetized, traheally cannulated mice (RD50TC). Both allylamine and diallylamine showed RD50 values of 9 ppm and 4 ppm, respectively, while the RD50 values associated with exposure to saturated amines ranged from 50 to 200 ppm. Among the eight amines tested for both upper airway irritation and pulmonary toxicity, diisopropylamine and di‐n‐butylamine showed a RD50TC/RD50 ratio of n‐butylamine should be specified.