Interrelation of stromal NAD(P)ase and human erythrocytic 6-phosphogluconic dehydrogenase.

Abstract
Red cell membranes induce inactivation and change in structure of hemolysate 6-phosphogluconic dehydrogenase in vitro in the presence of NADP. NAD(P)ase, present in the red cell membranes, splits NADP, and one of the products, 2[image]-phosphoadenosine diphosphate ribose, modifies the structure and the activity of 6-phosphogluconlc dehydrogenase.