Expression and functional characterization of ABCG2 in brain endothelial cells and vessels
Open Access
- 1 September 2003
- journal article
- fj express-summaries
- Published by Wiley in The FASEB Journal
- Vol. 17 (14) , 1-24
- https://doi.org/10.1096/fj.02-1131fje
Abstract
Delivery of drugs to the brain is impeded by the activity of efflux pumps expressed by endothelial cells of brain vasculature. The ATP binding cassette (ABC) transporters, among which ABCB1/MDR1 P-gl...Keywords
This publication has 44 references indexed in Scilit:
- Drug efflux transporters in the CNSAdvanced Drug Delivery Reviews, 2003
- Molecular and functional MDR1‐Pgp and MRPs expression in human glioblastoma multiforme cell linesInternational Journal of Cancer, 2002
- Overexpression of Multiple Drug Resistance Genes in Endothelial Cells from Patients with Refractory EpilepsyEpilepsia, 2001
- P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brainNeuroReport, 2001
- Neurotrophic and Neuroprotective Actions of Estrogens and Their Therapeutic ImplicationsAnnual Review of Pharmacology and Toxicology, 2001
- The Human ATP-Binding Cassette (ABC) Transporter SuperfamilyGenome Research, 2001
- The Roles of P-Glycoprotein and MRP1 in the Blood-Brain and Blood-Cerebrospinal Fluid BarriersPublished by Springer Nature ,2001
- Transporter-Mediated Permeation of Drugs Across the Blood–Brain BarrierJournal of Pharmaceutical Sciences, 2000
- P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugsInt. Journal of Clinical Pharmacology and Therapeutics, 2000
- THE CELL BIOLOGY OF THE BLOOD-BRAIN BARRIERAnnual Review of Neuroscience, 1999