THE EFFECT OF INTRAVENOUS INFUSIONS OF PHYSIOLOGIC SALINE SOLUTION ON THE PULMONARY ARTERIAL AND PULMONARY CAPILLARY PRESSURE IN MAN 1

Abstract
In the normal human subject the pulmonary arterial and the pulmonary capillary pressure can be significantly increased by the rapid intravenous infusion of physiologic saline soln. The pulmonary and the general blood volumes increase proportionately after this maneuver. The cardiac output after a rapid infusion may or may not increase. There is a linear correlation between the resting pulmonary arterial pressure and the general blood volume in normal subjects, but this relationship is not apparent in the case of the pulmonary blood volume as measured by the dye technic. The same relationship continues after an increase in the blood volume with saline soln. It is suggested that the changes induced by a rapid infusion can be explained most adequately on the basis of an abrupt, but not disproportionate, increase in the amt. of blood contained in the relatively indistensible pulmonary circuit.

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