The mode of inheritance of psoriasis: Evidence for a major gene as well as a multifactorial component and its implication for genetic counselling
- 1 October 1984
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 68 (1) , 73-76
- https://doi.org/10.1007/bf00293877
Abstract
Complex segregation analysis of Lomholt's family data on psoriasis on the Faroe Islands gave evidence for an additive major gene with gene frequency of 0.07 and penetrance 0.12 and 0.44 in the heterozygote and in the homozygote, respectively. In addition, there was a multifactorial component with heritability 0.87. The implications of these findings for genetic counseling are discussed and analytical risk figures are presented for chosen pedigrees.This publication has 15 references indexed in Scilit:
- Advances in Genetics in DermatologyPublished by Springer Nature ,1982
- Complex Segregation Analysis with PointersHuman Heredity, 1981
- Probability Calculations in Pedigrees under Complex Modes of InheritanceHuman Heredity, 1979
- Analysis of family resemblance. 3. Complex segregation of quantitative traits.1974
- On the genetics of psoriasisJournal of Genetics, 1974
- The Inheritance of PsoriasisJournal of Investigative Dermatology, 1973
- On the genetics of psoriasisArchives of Dermatological Research, 1973
- The Genetics of PsoriasisArchives of Dermatology, 1972
- Heredity and PsoriasisArchives of Dermatology, 1963
- Inheritance of Psoriasis in a Utah KindredArchives of Dermatology, 1961