Inhibition by Verapamil of Ischemic Ca2+ Uptake in the Rabbit Hippocampus

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Abstract
In the study described here a perfusion-dialysis system was used for recording ionic changes in the hippocampus during ischemia. Local perfusion with a Ca2+ entry blocker (verapamil) inhibited the fall in extracellular Ca2+ concentration which occurs in ischemia. The data consequently suggest that intracellular Ca2+ accumulation during ischemia can be blocked. A Ca2+ antagonist such as verapamil may thus improve postischemic neuronal recovery via a direct effect on parenchymal cells in addition to the previously suggested vascular effects.