Effect of Ehrlich Ascites Tumor on Mammary Glands of Mice of Low and High Mammary-Cancer Strains2

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Abstract
Ehrlich ascites tumor (EAT) transplants stimulated adjacent mammary-duct epithelium in C57BL mice. The presence of the ovaries and the consequent cyclic activity in the mammary gland during the course of the experiment did not modify the response of the mammary glands to the tumor stimulus. The stimulation consisted of cell enlargement and cell proliferation, with maximal mitotic activity on the 2d day after tumor inoculation. Inward proliferation of mammary-duct cells resulted in an increased height of the mammary-duct lining and diminution of duct lumen. Mammary-duct stimulation was confined to a 1 mm zone around the tumor transplant, but not all ducts in this area were affected. Greatest mitotic activity was found in mammary ducts which were not separated from the tumor transplant by an intervening layer of connective tissue. No apparent correlation existed between the genetic susceptibility of mammary glands to carcinogenesis and their sensitivity to the tumor stimulus. Mammary-duct cells of C3H mice, with a high incidence of spontaneous mammary cancer, were less responsive to the mitogenic effect of the tumor transplants than the mammary glands of the low mammary-cancer strain of C57BL mice. Mammary glands of DBA mice, another high mammary-cancer strain, resembled those of the C57BL strain.

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