Changes in Calcium Homeostasis during Aging and Alzheimer's Diseasea
- 17 December 1989
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 568 (1) , 262-270
- https://doi.org/10.1111/j.1749-6632.1989.tb12515.x
Abstract
SUMMARY: Several observations indirectly suggest that intracellular calcium regulation may be altered by aging and Alzheimer's disease. Thus, calcium homeostasis was examined directly in skin fibroblasts from Alzheimer's patients and compared to cells from normal young and elderly controls. Alterations in both bound and free calcium were noted; cells from Alzheimer's donors have higher levels of bound calcium but lower concentrations of free intracellular calcium when compared to cells from young and normal aged donors. These changes in calcium homeostasis may be physiologically significant, since processes that require transient elevations of intracellular free calcium, such as cell spreading, decline in the Alzheimer's cells. In summary, cultured skin fibroblasts from normal aged and Alzheimer's patients demonstrate deficits in calcium homeostasis and other metabolic processes when compared to cells from young donors.Keywords
This publication has 40 references indexed in Scilit:
- Reduced proliferation in T lymphocytes in aged humans is predominantly in the CD8+ subset, and is unrelated to defects in transmembrane signaling which are predominantly in the CD4+ subsetExperimental Cell Research, 1989
- Altered response of fibroblasts from aged and Alzheimer donors to drugs that elevate cytosolic free calciumNeurobiology of Aging, 1988
- The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21Science, 1987
- Ion channels in rabbit cultured fibroblastsProceedings of the Royal Society of London. B. Biological Sciences, 1986
- Quantitating the OccultNew England Journal of Medicine, 1985
- Altered Calcium Uptake in Cultured Skin Fibroblasts from Patients with Alzheimer's DiseaseNew England Journal of Medicine, 1985
- Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengthsCell Calcium, 1985
- Reduced calcium uptake by rat brain mitochondria and synaptosomes in response to agingBrain Research, 1985
- Some mitogens cause rapid increases in free calcium in fibroblastsFEBS Letters, 1984
- Calcium and vitamin D metabolism in guamanian chamorros with amyotrophic lateral sclerosis and parkinsonism–dementiaAnnals of Neurology, 1984