Convulsive and hypothermic effects of vasopressin in the brain of the rat
- 1 March 1980
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 58 (3) , 316-319
- https://doi.org/10.1139/y80-054
Abstract
Arginine vasopressin (AVP) was administered into the lateral cerebral ventricles of rats to assess its effects when given directly into the brain. AVP (1.0 μg) caused an immediate sharp decrease in body temperature. Behaviorally, AVP caused short pauses of immobility and staring upon the first injection but the same dose caused myoclonic–myotonic convulsions upon the second injection 2 days later. Thereafter, as little as 10 ng of AVP caused seizures.This publication has 0 references indexed in Scilit: