A MALDI Sample Preparation Method Suitable for Insoluble Polymers
- 5 February 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 72 (7) , 1707-1710
- https://doi.org/10.1021/ac991181u
Abstract
Polyamides are insoluble or poorly soluble in common organic solvents, which makes normal sample preparation for matrix-assisted laser desorption/ ionization (MALDI) mass spectrometry very difficult. An new analytical protocol for MALDI analysis of polyamides or other insoluble samples is described. It consists of pressing a pellet from a solid mixture of the polymer and a matrix, both in the form of finely ground powder. This sample preparation is compared with the common dried droplet sample preparation method and found to perform much better, both in terms of robustness against variation of experimental parameters and high-mass capability.Keywords
This publication has 9 references indexed in Scilit:
- Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for polymer analysis: solvent effect in sample preparationJournal of the American Society for Mass Spectrometry, 1998
- MALDI-TOF mass spectrometry in the analysis of synthetic polymersActa Polymerica, 1998
- Novel Procedure for Molecular Weight Averages Measurement of Polydisperse Polymers Directly from Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass SpectraRapid Communications in Mass Spectrometry, 1996
- Why Does Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry Give Incorrect Results for Broad Polymer Distributions?Rapid Communications in Mass Spectrometry, 1996
- Mass Discrimination Effects in an Ion Detector and Other Causes for Shifts in Polymer Mass Distributions Measured by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass SpectrometryMacromolecules, 1996
- On the mechanism and control of salt-induced resolution loss in matrix-assisted laser desorption/ionizationEuropean Journal of Mass Spectrometry, 1996
- Polymer molecular weight distribution: Results from matrix-assisted laser desorption ionization compared with those from gel-permeation chromatographyRapid Communications in Mass Spectrometry, 1995
- Mass spectrometry of synthetic polymers by UV-matrix-assisted laser desorption/ionizationAnalytical Chemistry, 1992
- Preparation and properties of high molar mass nylon-4,6: a new development in nylon polymersPolymer, 1985