Using Jasplakinolide to Turn on Pathways that Enable the Isolation of New Chaetoglobosins from Phomospis asparagi
- 29 October 2005
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 68 (11) , 1592-1597
- https://doi.org/10.1021/np050293f
Abstract
The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines.Keywords
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