The pattern of adsorption of cationic antiseptics to polymethylmethacrylate

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Abstract
Few studies have reported the maximum potential of surfaces to absorb the cationic antiseptics and few comparisons between antiseptics have been carried out. The purpose of this investigation was to measure the maximum uptake of alexidine, cetyl pyridinium chloride, chlorhexidine gluconate and chlorhexidine acetate to polymethylmethacrylate and by the construction of absorption isotherms determine the pattern of molecular attachment to the recipient surface. The mean maximum adsorption findings for these antiseptics demonstrated significantly greater uptake of cetyl pyridinium chloride than the other antiseptics and significantly less uptake of alexidine compared with the other antiseptics. All 4 antiseptics showed a Langmuir type adsorption isotherm consistent with the formation of a monolayer of molecules on the recipient surface. The pattern of adsorption apparently was not altered by [human] saliva pretreatment of surfaces. No evidence of molecular multilayering was observed even at higher concentrations of the antiseptics. However, the maximum uptake on to the surface was significantly increased when no posttreatment washings were carried out. This increased uptake evidently would be unlikely to play an important role in antiplaque activity because of its relative instability. The pH dependency for the adsorption of these antiseptics was demonstrated such that as previously observed for chlorhexidine gluconate at low pH adsorption is almost completely, or completely, prevented.

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