Influence of cadmium on renal ischemic hypertension in rats

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Abstract
In order to ascertain whether or not Cd is an accessory factor in experimental renal hypertension, rats were subjected to partial constriction of the left renal artery. A third were given drinking water containing 50 ppm zinc, 1/3 given 5 ppm cadmium, and 1/3 deionized water, and maintained in an environment and on a diet low in Cd. Systolic blood pressures, measured for 2-6 weeks, showed that animals given Cd exhibited higher levels of hypertension than did those not given Cd. Hypertension developed within 3 weeks of feeding Cd to normotensive operated males. Reduction of renal mass was associated with a loss of Zn but no loss of renal Cd. Hypertrophy of the opposite kidney was associated with gain in Zn, except in animals fed Cd. The ratio of Cd to Zn was elevated in the operated kidneys of animals on low Cd intakes and in both kidneys of animals fed Cd. Since all commercial diets contain Cd, small intakes may enhance experimental renal hypertension.

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