Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction
- 20 December 1996
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 8 (1) , 11-14
- https://doi.org/10.1097/00001756-199612200-00003
Abstract
NTERLEUKIN-2 (IL-2) was found to have an analgesic effect in the peripheral nervous system. Both electro- physiological and behavioural experiments suggested an anti-noceiceptive effect of IL-2 in animals. Biochemical experiments revealed that IL-2 could displace diprenorphine binding in both NG 108-15 cells and HEK 293 cells transfected with pCDNA3-DOR (δ opioid receptor). Furthermore, IL-2 significantly inhibited cAMP production stimulated by forskolin in both NG 108-15 and transfected HEK 293 cells, indicating that the binding of IL-2 to the δ opioid receptor is functional.Keywords
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