Lipopolysaccharide-Instructed, Cryopreserved, Human Monocytes Sequentially Convert Plasma Fibrinogen to Fibrin and Lyse the Fibrin Formed

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Abstract
Cryopreserved human monocytes have been examined for their procoagulant and profïbrinolytic capacities on lipopolysaccharide (LPS) stimulation, when given the possibility to act upon fibrinogen in heparinized plasma. As shown by the appearance of fibrinopeptide A, indicating thrombin action on the fibrinogen molecule, and by the appearance of D-Dimer, indicating the action of plasmin on fibrin, it is apparent that LPS-instructed monocytes give rise to fibrin which is subsequently lysed. Thus, delineation (fibrin formation) appears to be followed by fibrin removal (restitution).

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