BCG Induced Murine Peritoneal Exudate Cells: Cytotoxic Activity Against a Syngeneic Bladder Tumor Cell Line

1 June 1982

journal article
research article
Published by Wolters Kluwer Health in Journal of Urology

Vol. 127 (6) , 1225-1229
https://doi.org/10.1016/s0022-5347(17)54303-7

Abstract

Peritoneal exudate cells from mice after i.p. injection of 10 mg of BCG demonstrated cytolytic activity in vitro against the syngeneic [mouse] bladder tumor cell line MBT-2. The cytolytic effector cells are nonadherent, nonphagocytic and trypsin resistant. These cells are cyclophosphamide- and hydrocortisone-sensitive. A NK[natural killer]-like cell probably constitutes the major, if not all, the population of effector cells in this reaction.

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