BINDING AND ACTIVATION PROPERTIES OF ANGIOTENSIN II IN DISPERSED RAT ANTERIOR PITUITARY CELLS1
- 1 March 1982
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 110 (3) , 1043-1045
- https://doi.org/10.1210/endo-110-3-1043
Abstract
The properties of angiotensin II receptors were studied in isolated rat anterior pituitary cells prepared by trypsin digestion. Angiotensin II bound in a time-and temperature-dependent manner to pituitary cells, with Kd of 4.1 × 10-9 M. The heptapeptide, des-Asp-1-angiotensin II, had only one-tenth of the affinity of the octapeptide (Ki = 5.5 × 10-8 M). These two peptides displayed a similar potency ratio in their ability to stimulate ACTH release from pituitary cells. These results indicate that angiotensin II may play a regulatory role in controlling ACTH secretion from the pituitary gland.Keywords
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