A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations
- 13 September 2005
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 65 (5) , 741-744
- https://doi.org/10.1212/01.wnl.0000172630.22804.73
Abstract
Referral-based studies indicate that a mutation (G2019S) in exon 41 of the LRRK2 gene might be a common cause of Parkinson disease (PD). The authors sequenced leucine-rich repeat kinase 2 (LRRK2) exons 31, 35, and 41 in 371 consecutively recruited patients with PD and found mutations in six (1.6%) subjects, including two heterozygous for new putative pathogenic variants (R1441H, IVS31 + 3A→G). These data confirm the important contribution of LRRK2 to PD susceptibility in a clinic-based population.Keywords
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