COMPARATIVE-STUDY OF HYDROCHLOROTHIAZIDE AND A FIXED COMBINATION OF METOPROLOL AND HYDROCHLOROTHIAZIDE IN ESSENTIAL-HYPERTENSION

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 13, 37-44
Abstract
In a double-blind study comprising 31 patients with essential hypertension not satisfactorily controlled on hydrochlorothiazide 25 mg o.m. [every morning] a fixed-ratio combination of metoprolol 100 mg and hydrochlorothiazide 12.5 mg, given as 2 tables o.m. was compared with hydrochlorothiazide 50 mg o.m. monotherapy. With the combination regimen a significant reduction of blood pressure was achieved while doubling of the thiazide dose did not adequately control the blood pressure. In 7 patients in the thiazide-group the therapy was changed to the combination during a follow-up period and their blood pressure was normalized. During the follow-up period, 22 patients were treated with the fixed combination; 50% of them were controlled on 1 tablet o.m. The tolerability was good in both groups and no changes were observed regarding laboratory variables except for an increase in serum uric acid in the thiazide-group. A fixed-ratio combination of hydrochlorothiazide 12.5 mg and metoprolol 100 mg in a dose of 1 or 2 tablets once daily is a well tolerated and more effective therapy than hydrochlorothiazide 50 mg once daily monotherapy.