RecQ helicases: lessons from model organisms
Open Access
- 26 August 2006
- journal article
- review article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 34 (15) , 4106-4114
- https://doi.org/10.1093/nar/gkl557
Abstract
RecQ DNA helicases function during DNA replication and are essential for the maintenance of genome stability. There is increasing evidence that spontaneous genomic instability occurs primarily during DNA replication, and that proteins involved in the S-phase checkpoint are a principal defence against such instability. Cells that lack functional RecQ helicases exhibit phenotypes consistent with an inability to fully resume replication fork progress after encountering DNA damage or fork arrest. In this review we will concentrate on the various functions of RecQ helicases during S phase in model organisms.Keywords
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