Endocrinologic studies in men exposed occupationally to carbon disulfide

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Abstract
The effect of long-term occupational exposure to CS2 on various endocrinologic parameters was studied in 15 exposed men and 16 age-matched controls. Duration of exposure was 10-36 yr. CS2 concentrations in the viscose rayon plant were below the Finnish threshold limit of 30 mg/m3 (10 ppm) under normal operating conditions for the past 10 yr. Before this, the exposure was greater. Of the various endocrinologic parameters, serum follicle stimulating hormone and luteinizing hormone were significantly increased in the exposed group, 7 workers having values above the reference limit. This was taken as a sign of primary gonadal insufficiency which was considered latent as serum testosterone values were unaffected. No changes were seen in serum prolactin values after stimulation with thyrotropin releasing hormone [TRH]. No disturbance was seen in thyroid function as evaluated by serum thyroxine, free thyroxine index, triiodothyronine and thyrotropin response to TRH. Serum cortisol was unchanged. These results may reflect high exposure during past decades rather than exposure to the present low CS2 concentrations.