Elucidation of the structure of the antineoplastic agents, 2-formylpyridine and 1-formylisoquinoline thiosemicarbazones
- 1 March 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (3) , 447-449
- https://doi.org/10.1021/jm00213a024
Abstract
The geometrical isomers of the antineoplastic agents 2-formylpyridine and 1-formylisoquinoline thiosemicarbazones were synthesized and their structure was studied by spectroscopic methods. The compounds previously described in the literature and tested for carcinostatic activity were isomers with E configuration which probably contained minor amounts of Z isomers.This publication has 1 reference indexed in Scilit:
- The Carcinostatic Activity of Thiosemicarbazones of Formyl Heteroaromatic Compounds.1 III. Primary CorrelationJournal of Medicinal Chemistry, 1966