Increase in Plasma Concentrations of 3,5,3′-Triiodothyronine and Thyroxine after a Meal, and its Dependence on Energy Intake

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Abstract
Plasma concentrations of 3,5,3′ triiodothyronine (T3) and thyroxine (T4) were measured before, during and for between 2 and 6 hr following a meal, in young growing piglets. T3 increased after a meal and reached a peak at approximately 60 min. The magnitude of the rise was dependent on both the energy content and nutrient composition of the meal. In animals given either a high or low energy intake baseline values of T3 were similar, whereas there was a difference in the response to a meal (P< 0.01). Average increases in hormone concentrationwere 120% (P< 0.001) and 50% (P< 0.05) on the high and low intakes respectively. Plasma T4 also increased in those on the high intake (P< 0.025), but no change was detected when the intake was low. The response of T3 to a meal high in either glucose, sucrose, fat or protein was statistically significant except for the protein meal. The rise in T4 after each of these four meals was less consistent, although it did increase significantly after meals high in sucrose or fat. Amongst several possibilities, these results suggest that a meal may induce an increase in secretion of T3 and T4 from the thyroid gland.

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