Demecarium bromide (BC-48 or Humorsol) and echothiophate (Phospholine) iodide are potent long acting inhibitors of cholinesterase.1-5 They improve outflow facility and lower intraocular pressure in both normal and glaucomatous eyes.6,7 In contrast to isoflurophate (DFP), they are water soluble and more stabile. The present study is an evaluation of these agents in a series of patients with glaucoma uncontrolled on other forms of therapy. Method All patients selected for these series had been on various other forms of therapy (pilocarpine, carbachol, physostigmine, epinephrine bitartrate, carbonic anhydrase inhibitors) and had been judged to be unsuccessfully controlled (intraocular pressure over 24 mm. Hg). Demecarium bromide therapy was initiated in 144 eyes of 76 patients; and echothiophate iodide was started in 155 eyes of 83 patients.* As indicated in Table 1, chronic simple glaucoma predominated in both series with a small number of secondary and postoperative (iridectomy) angle-closure glaucomas. Patients were