Induction of a Transient Reaginic Antibody to Tartrazine in an Animal Model

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Abstract
The capacity of tartrazine to initiate reaginic antibody production was investigated in inbred rats. Parenteral administration of tartrazine, when covalently linked to a protein carrier and presented in association with carrageenan, resulted in the production of a transient tartrazine-specific reaginic antibody. This response could be enhanced by a secondary challenge, but declined rapidly and thereafter could not be reelicited.

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