The GBV-C envelope glycoprotein E2 does not interact specifically with CD81
- 11 May 2007
- journal article
- Published by Wolters Kluwer Health in AIDS
- Vol. 21 (8) , 1045-1048
- https://doi.org/10.1097/qad.0b013e3280f77412
Abstract
The addition of GB virus C (GBV-C) E2 protein to cells inhibits HIV replication in vitro, presumably triggered by interactions with a specific cellular receptor. Indirect evidence suggests that CD81 is the GBV-C E2 cellular receptor. We found that E2 binding to cells was not dependent upon human CD81, and that soluble CD81 did not compete with GBV-C E2 for cell binding. GBV-C E2 protein thus does not appear to interact with CD81.Keywords
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