Immunohistochemical Study of c-erbB-2 Oncoprotein Expression in Extramammary Paget’s Disease
- 1 January 1994
- journal article
- Published by S. Karger AG in Dermatology
- Vol. 188 (2) , 100-102
- https://doi.org/10.1159/000247110
Abstract
Sections of formalin-fixed, paraffin-embedded tumor tissue from 20 patients with noninvasive extramammary Paget's disease and 2 patients with invasive extramammary Paget's disease were stained immunohistochemically by means of anti-c-erbB-2 product monoclonal antibody. Membrane staining of intraepidermal tumor cells was found in only 3 of 20 cases of noninvasive extramammary Paget's disease. In the 2 invasive cases, tumor cells of invasive lesions and metastases were positive while intraepidermal tumor cells were negative.Keywords
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