Insulin antagonises the growth hormone‐mediated increase in the activity of phosphatidate phosphohydrolase in isolated rat hepatocytes
- 23 June 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 202 (1) , 133-136
- https://doi.org/10.1016/0014-5793(86)80663-9
Abstract
Rat hepatocytes were incubated in monolayer culture, under serum‐free conditions for 8 h. Rat growth hormone (up to 100 nM) increased the activity of phosphatidate phosphohydrolase by up to 41%. Insulin (500 pM or 35 nM), cycloheximide or actinomycin D reversed this effect. The ability of growth hormone to modify the effects of insulin is discussed in relation to the control of the phosphohydrolase activity and glycerolipid synthesis.Keywords
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