Inhibition of potassium-stimulated release of [3H]dopamine from rat striata as a result of prior exposure to cocaine, nomifensine, or mazindol
- 1 March 1980
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 5 (3) , 345-349
- https://doi.org/10.1007/bf00964622
Abstract
The nerve terminals in the striata of rat brain were labeled in vitro with [3H]dopamine via the uptake mechanism for catecholamines. Subsequently, the striata were incubated with cocaine, nomifensine, or mazindol, inhibitors of catecholamine uptake. The tissues were rinsed in fresh medium and then stimulated with 20 mM potassium to induce release of [3H]dopamine. Under these conditions, each drug decreased the potassium-stimulated release of radioactivity by 40–50% compared to control tissues which had not been exposed to the drugs.This publication has 14 references indexed in Scilit:
- PRESYNAPTIC ADRENOCEPTORS AND REGULATION OF RELEASEPublished by Elsevier ,1979
- Studies on the capacity of mazindol and dita to act as uptake inhibitors or releasing agents for 3H-biogenic amines in rat brain tissue slicesEuropean Journal of Pharmacology, 1977
- Mazindol and amphetamine as inhibitors of the uptake and releasers of 3H-dopamine by rat striatal synaptosomesNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1977
- The effect of carbonyl‐binding agents on the potassium‐evoked release of [3H]catecholamines from brain and peripheral tissuesJournal of Neurochemistry, 1977
- Studies on brain metabolism of biogenic amines.British Journal of Clinical Pharmacology, 1977
- Regulation of noradrenaline release by presynaptic receptor systemsPublished by Springer Nature ,1977
- Studies on the distinction between uptake inhibition and release of [3H]dopamine in rat brain tissue slicesBiochemical Pharmacology, 1975
- Effect of nomifensine (Hoe 984), a new antidepressant, on uptake of noradrenaline and serotonin and on release of noradrenaline in rat brain synaptosomesBiochemical Pharmacology, 1974
- Nomifensine: a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatumJournal of Pharmacy and Pharmacology, 1974
- Drug‐Induced Changes in the Release of3H‐Monoamines from Field Stimulated Rat Brain SlicesActa Physiologica Scandinavica, 1971