Localized gene action controlling intestinal neoplasia in mice
Open Access
- 27 May 1997
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 94 (11) , 5848-5853
- https://doi.org/10.1073/pnas.94.11.5848
Abstract
Mice heterozygous for the ApcMin (Min) mutation develop adenomas throughout the intestinal tract. Apc is believed to be involved in cell migration, adhesion, and polarity. Adenoma multiplicity and growth rate are modulated by an unlinked modifier locus, Mom1. The secretory phospholipase Pla2g2a is a candidate for Mom1. Here, we investigate the range of action of Apc and Mom1. Analysis of chimeric Min mice indicates that the actions of both Apc and Mom1 are localized within the cell lineage that gives rise to intestinal tumors.Keywords
This publication has 34 references indexed in Scilit:
- Studies of neoplasia in the Min mouseBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1997
- Mammalian non-pancreatic phospholipases A2Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1993
- Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC GeneScience, 1992
- The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.The Journal of cell biology, 1992
- Phospholipase A2 — a mediator between proximal and distal effectors of inflammationImmunology Today, 1991
- Identification of FAP Locus Genes from Chromosome 5q21Science, 1991
- Identification and characterization of the familial adenomatous polyposis coli geneCell, 1991
- A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the MouseScience, 1990
- Derivation of mouse intestinal crypts from single progenitor cellsNature, 1985
- The kinetics of villus cell populations in the mouse small intestine.Cell Proliferation, 1982