Elevated serum bleomycin-detectable iron concentrations in patients with sepsis syndrome

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Abstract
To determine serum bleomycin-detectable ‘free’ iron in patients with septic shock and to relate these findings to both outcome and a marker of free radical damage. A prospective observational study. A nine-bed intensive care unit in a university teaching hospital. Sixteen consecutive patients with septic shock, defined as: (1) Clinical evidence of acute infection; (2) hypo- or hyperthermia (38.3°C); (3) tachypnoea (>20 breaths/min or ventilated); (4) tachycardia (>90 beats min); (5) shock (systolic pressure PPPr=0.54,P<0.05). The present study provides evidence of lipid peroxidation in patients who die with septic shock. The data suggest that ironcatalysed hydroxyl radical generation does not form an important contribution to this lipid peroxidation in patients with sepsis.