Hemolysin Formation in Mice Following Partial, Total Splenectomy or Spleen Transplantation

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Abstract
Ability of partially splenectomized NIH mice to form hemolysln following intravenous immunization with sheep erythrocytes was related to the amount of remnant spleen tissue. When the remaining spleen tissue was reduced below 0.2-0.3% of the body weight, hemolysin titers were correspondingly lowered. Since total splenectomy completely suppressed hemolysin formation following intravenous immunization, but reduced the average titer by about 27% after intraperitoneal immunization, it was concluded that the spleens of the mice in these experiments served chiefly as filter organs. Complete suppression of antibody formation was partially reversed by autologous spleen transplants in the splenectomized mice of 2 strains; by isologous transplants in Balb/c but not in NIH mice; and unaffected by homologous spleen transplants in either of the 2 strains.

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