Specific Antibody Levels in the Serum of Heligmosomoides polygyrus-Infected Mice

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Abstract
Sera from ICR/CD1 mice were assayed by radial immunodiffusion following oral infection and challenge with H. polygyrus larvae. Infection of these mice altered the concentrations and classes of immunoglobulins [Ig], as well as the levels of antiparasitic antibody. Challenge of single- or multiple-infected mice with viable larvae resulted in the appearance of anti-H. polygyrus IgA and IgG1 in the serum. The kinetics of the detection for both of these antibody classes were consistent with an anamnestic response to an antigen isolated from adult nematodes. There seemed to be an association in resistant mice of serum IgA levels with early and late events in the life cycle of the parasite.

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