Complex Endemic Situation Regarding Extended-Spectrumβ-Lactamase-ProducingKlebsiella pneumoniaein a Hospital in Slovenia
- 1 October 2003
- journal article
- Published by Mary Ann Liebert Inc in Microbial Drug Resistance
- Vol. 9 (supplement) , 25-33
- https://doi.org/10.1089/107662903322541865
Abstract
The first detailed epidemiological study of extended-spectrum beta-lactamase (ESBL)-producing organisms identified in Slovenia was carried out. It was performed on a group of 40 Klebsiella pneumoniae isolates that were randomly selected from all putative ESBL producers of this species recovered in a large hospital in Celje in 1997-2001. At least three different ESBLs, SHV-2, -5, and -12, were produced by the isolates and these enzymes seem to be common in nosocomial Enterobacteriaceae populations in countries of the region (e.g., Italy, Hungary, Croatia). The analysis revealed a complex epidemiology of the organisms, illustrated mostly by their high clonal variety but also by the diversity of their beta-lactamase and plasmid content, mating capability, and antimicrobial susceptibility. Although some cases of a 'fresh' dissemination of strains or plasmids could be identified, the overall situation should be described rather as endemic, and its complexity may be in part attributed to the late introduction of the ESBL detection procedure to the hospital.Keywords
This publication has 44 references indexed in Scilit:
- Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance ThreatClinical Microbiology Reviews, 2001
- Outbreak of Infection with Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae in a Mexican HospitalJournal of Clinical Microbiology, 2001
- Molecular Epidemiology of Extended-Spectrum β-Lactamases from Klebsiella pneumoniae Strains Isolated in Zagreb, CroatiaEuropean Journal of Clinical Microbiology & Infectious Diseases, 2001
- Coexistence of SHV-4- and TEM-24-Producing Enterobacter aerogenes Strains before a Large Outbreak of TEM-24-Producing Strains in a French HospitalJournal of Clinical Microbiology, 2001
- Complexity and Diversity of Klebsiella pneumoniae Strains with Extended-Spectrum β-Lactamases Isolated in 1994 and 1996 at a Teaching Hospital in Durban, South AfricaAntimicrobial Agents and Chemotherapy, 2001
- Extended-spectrum β-lactamases: how big is the problem?Clinical Microbiology & Infection, 2000
- Are SHV β-Lactamases Universal in Klebsiella pneumoniae ? Antimicrobial Agents and Chemotherapy, 2000
- Outbreak of a Multiresistant Klebsiella pneumoniae Strain in an Intensive Care Unit: Antibiotic Use as Risk Factor for Colonization and InfectionClinical Infectious Diseases, 2000
- Concurrent outbreaks of extended-spectrum β-lactamase-producing organisms of the family Enterobacteriaceae in a Warsaw hospitalJournal of Antimicrobial Chemotherapy, 1999
- Is it important to identify extended-spectrum beta-lactamase-producing isolates?European Journal of Clinical Microbiology & Infectious Diseases, 1996