Depression of bovine monocyte chemotactic responses by bovine viral diarrhea virus

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Abstract
Incubation of bovine peripheral blood monocytes with bovine viral diarrhea virus [BVDV] (Singer or NY-1 strain) caused a consistent, statistically significant decrease in their random locomotion (no chemoattractant) and chemotaxis towards a chemotactic lymphokine. Chemotaxis was determined by a modification of the Boyden method. Incubation of BVDV with mononuclear cells depressed chemotaxis by 56% (P < 0.0005). Heat-killed virus had no effect on monocyte motility. BVDV can rapidly suppress monocyte functions in vitro by unknown mechanisms but not by killing cells.