Cerebrospinal fluid adenosine deaminase activity for the diagnosis of tuberculous meningitis in children
Open Access
- 1 June 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Tropical Pediatrics
- Vol. 42 (3) , 129-132
- https://doi.org/10.1093/tropej/42.3.129
Abstract
Adenosine deaminase (ADA) activity was measured in the cerebrospinal fluid (CSF) of 27 subjects suffering from tuberculous meningitis (TBM), 19 from bacterial meningitis, 10 from encephalitis, and 10 control subjects. The mean CSF ADA level was significantly raised (P5IU/l was considered for the diagnosis of TBM, and the test had sensitivity and specificity of 89 and 92 per cent, respectively. Overall, it was found to be a better test in comparison to any other single test for the diagnosis of TBM. Confirmed TBM patients had significantly higher CSF ADA activity when compared with clinical TBM (PPPP<0.02). Thus, the CSF ADA activity assay was found to be a simple, useful and rapid diagnostic test for the early recognition of TBM in children.Keywords
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