Variation in the Individual Subject of Some Parameters in Blood Coagulation and Fibrinolysis

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Abstract
Five young, healthy women with regular menstruations and who were not taking oral contraceptives were followed with repeated blood samples for 5 weeks. On each individual, about 15 determinations were made of the number of platelets, the fibrinogen and plasminogen concentration, the P & P‐test, the Factor VIII activity and the spontaneous fibrinolytic activity of the euglobulin fraction of plasma on fibrin plates. It was shown that the variation in these parameters in the individual was smaller than the variation between individuals and that distinct individual ranges could be found for some women. This was most pronounced with respect to the number of platelets, the fibrinogen concentration and the P&P‐test. The importance of knowing normal intra‐individual ranges of different parameters in blood coagulation and fibrinolysis is stressed.Cyclic variations in the number of platelets were found during the menstrual cycle but there were no such variations in the other parameters studied.