THE OXIDATION OF GLUCOSE AND ACETATE BY SACCHAROMYCES CEREVISIAE

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Abstract
Cells of S. cerevisiae harvested in the late logarithmic or stationary phases of growth oxidize glucose, ethanol, and acetate rapidly, while cells harvested in the early logarithmic phase oxidize only glucose appreciably. The inability of young cells to oxidize acetate cannot be explained on the basis of impermeability to this substrate but may be the result of a deficiency of certain tricarboxylic acid cycle enzymes. The oxidation of glucose by young cells proceeds well past the oxidation level of acetate. Evidence is presented concerning the mechanism of glucose oxidation by young cells, and the possibility of the existence of a new pathway is discussed.