Disposition of Biosynthesized Fatty Acids in Normal and Fasted Rats

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Abstract
Sodium acetate-1-C14 was injd. intraperitoneally into young, male Sprague-Dawley rats, and the fate of the biosynthesized fatty acids was studied 24 hrs. later. No significant difference was observed in distr. of biosynthesized fatty acids between neutral fat phospholipid fractions of various tissue fats in fed and 72-hr. fasted animals. In liver of the rats this ratio varied only slightly about 1.0, but in intestine, phospholipid fatty acids were more heavily labeled. Intramusc. fat had a ratio different than that of subcut. fat. Ratios between activities of saturated and unsaturated fatty acids in livers of fed and fasted animals were similar, but in carcass fat a higher ratio (i.e., the saturated acids were more heavily labeled) was observed in fasted animals. Total activity in the excreted fecal fatty acids was similar for fed and starved animals, but the specific activity of the fatty acids was higher in the case of starved animals.

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