β-Lactamases of Kluyvera ascorbata , Probable Progenitors of Some Plasmid-Encoded CTX-M Types
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Open Access
- 1 September 2002
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (9) , 3045-3049
- https://doi.org/10.1128/aac.46.9.3045-3049.2002
Abstract
Kluyvera ascorbata produces a β-lactamase that results in an atypical susceptibility pattern, including low-level resistance to penicillins, cephalothin, and cefuroxime, but this resistance is reversed by clavulanate. Ten nucleotide sequences of the corresponding gene, bla KLUA , were obtained and were found to have minor variations (96 to 100%). Otherwise, bla KLUA was found to be similar (95 to 100%) to some plasmid-encoded CTX-M-type β-lactamases. Finally, mobilization of bla KLUA on a plasmid was found to be mediated probably by a genetic mobile element like IS Ecp1 .Keywords
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