Clonal Proliferation of Lymphoid and Myeloid Progenitor Cells in Patients with Hematological Abnormalities1

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Abstract
Myeloid and lymphoid stem cell colony formation (GM-CFU and L-CFU) was studied in patients with lymphoproliferative diseases, aplastic anemia and other hematological abnormalities. Most children with acute lymphatic leukemia had low L-CFU number with decreased or normal GM-CFU, while in Hodgkin''s disease and chronic lymphatic leukemia L-CFU growth was very poor with only minor GM-CFU abnormalities. Aplastic anemia was characterized by decreased GM-CFU and normal L-CFU. Coculture studies suggested that a diminished colony formation may be linked to circulating lymphocytes that inhibit L-CFU and reduction in precursor cell number.