ATROPINE-INDUCED BRADYCARDIA IN GUINEA-PIG - DOSE-RESPONSE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 16  (3) , 401-410
Abstract
The effect of atropine sulfate on the heart rate of the unanesthetized guinea pig was studied using a wide range of doses injected via a chronic jugular cannula; dose-response data were presented for the range of 5-50 mg/kg. A long-lasting dose-dependent bradycardia was produced which was in contrast to the classically reported effect of atropine in man and dog: tachycardia sometimes preceded by a transient bradycardia. Thus, the guinea pig may be an excellent model for the study of parasympathomimetic, bradycardia-producing effects of atropine.

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